abstract：:Fetoplacental blood vessel constriction in response to reduced oxygenation has been demonstrated in placenta perfused in vitro. In pulmonary vessels, hypoxic vasoconstriction involves Ca2+ influx into smooth muscle through membrane ion channels including voltage-gated Ca2+ channels (VGCCs). We hypothesised that VGCCs ...

journal_title：Placenta

authors： Cooper EJ,Wareing M,Greenwood SL,Baker PN

更新日期：2006-04-01 00:00:00

abstract：:Intrauterine growth and development can impact upon the long-term health of an individual. The fetus is dependent upon the placenta for its supply of nutrients and oxygen from the mother. In turn, the functional capacity of the placenta to supply that demand is under the control of the fetal and maternal genomes. Rece...

journal_title：Placenta

authors： Angiolini E,Fowden A,Coan P,Sandovici I,Smith P,Dean W,Burton G,Tycko B,Reik W,Sibley C,Constância M

更新日期：2006-04-01 00:00:00

abstract：:Murine trophoblast stem (TS) cells express fibroblast growth factor receptor 2 (FGFR2) and are maintained in their proliferative state by fibroblast growth factor 4 (FGF4). We show in this report that in the first trimester human placenta FGFR2 expression is similarly found in a subset of villous cytotrophoblast and i...

journal_title：Placenta

authors： Baczyk D,Dunk C,Huppertz B,Maxwell C,Reister F,Giannoulias D,Kingdom JC

更新日期：2006-04-01 00:00:00

abstract：:Amino acid transport System A (SysA) activity is present within the rodent and human placentas. Inhibition of this transport system is associated with fetal growth retardation. Several cDNAs encoding SysA transport proteins have been discovered, and their presence documented within the human placenta. We have demonstr...

journal_title：Placenta

authors： Novak D,Lehman M,Bernstein H,Beveridge M,Cramer S

更新日期：2006-04-01 00:00:00

abstract：:Early placental development is characterised by rapid cell differentiation and migration, matrix remodelling and angiogenesis. The enzyme NAD(P)H oxidase is a major source of superoxide anions implicated in signalling pathways regulating these processes in other systems. It is also thought to be involved in oxygen sen...

journal_title：Placenta

authors： Raijmakers MT,Burton GJ,Jauniaux E,Seed PT,Peters WH,Steegers EA,Poston L

更新日期：2006-02-01 00:00:00

abstract：:This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...

journal_title：Placenta

authors： Santos TC,Dantzer V,Jones CJ,Oliveira MF,Miglino MA

更新日期：2006-02-01 00:00:00

abstract：:Bovine nuclear transfer pregnancies are characterized by a high incidence of placental abnormalities, notably, increased placentome size and deficiencies in trophoblast cell function and establishment of placental vasculature. Alterations in gene expression during placental growth and development may contribute to the...

journal_title：Placenta

authors： Ravelich SR,Shelling AN,Wells DN,Peterson AJ,Lee RS,Ramachandran A,Keelan JA

更新日期：2006-02-01 00:00:00

abstract：:Placenta accreta is a pregnancy complication characterized by the presence of life-threatening uteroplacental neovascularization. The factors involving its development are unknown. Vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors (VEGFR) have important roles in vascular remo...

journal_title：Placenta

authors： Tseng JJ,Chou MM,Hsieh YT,Wen MC,Ho ES,Hsu SL

更新日期：2006-01-01 00:00:00

abstract：:Human trophoblast research relies on a combination of in vitro models, including isolated primary cultures, explant cultures, and trophoblast cell lines. In the present study, we have utilized the rotating wall vessel (RWV) bioreactor to generate a three-dimensional (3-D) model of human placentation for the study of c...

journal_title：Placenta

authors： LaMarca HL,Ott CM,Höner Zu Bentrup K,Leblanc CL,Pierson DL,Nelson AB,Scandurro AB,Whitley GS,Nickerson CA,Morris CA

更新日期：2005-11-01 00:00:00

abstract：:The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...

journal_title：Placenta

authors： Correia-da-Silva G,Bell SC,Pringle JH,Teixeira NA

更新日期：2005-11-01 00:00:00

abstract：:Placentas and plasma from women with and without Chagas' disease and cultures of human placental villi with Trypanosoma cruzi, neuraminidase, phospholipase A2 and phospholipase C were analyzed in order to verify if the alterations in placental alkaline phosphatase (PLAP) enzyme activity are caused by T. cruzi as obser...

journal_title：Placenta

authors： Lin S,Sartori MJ,Mezzano L,de Fabro SP

更新日期：2005-11-01 00:00:00

abstract：:Dietary taurine is essential for cats and deficiency during pregnancy may lead to abortion, growth restriction or impaired neurological function of kittens. We previously described Na(+)- and Cl(-)-dependent taurine transport by system beta in fragments of freshly isolated cat placenta [Champion EE, Bailey SJ, Glazier...

journal_title：Placenta

authors： Champion EE,Mann SJ,Glazier JD,Jones CJ,Rawlings JM,Sibley CP,Greenwood SL

更新日期：2005-09-01 00:00:00

abstract：:Several recent publications have focused on the association between the occurrence of twin-to-twin transfusion syndrome (TTTS) in diamniotic-monochorionic twins and the presence of a number of selected anatomic placental characteristics (distribution of vascular territory, cord insertion, type and number of inter-twin...

journal_title：Placenta

authors： De Paepe ME,DeKoninck P,Friedman RM

更新日期：2005-07-01 00:00:00

abstract：:Pregnant mothers are exposed to a wide variety of foreign chemicals. This exposure is most commonly due to maternal medication, lifestyle factors, such as smoking, drug abuse, and alcohol consumption, or occupational and environmental sources. Foreign compounds may interfere with placental functions at many levels e.g...

journal_title：Placenta

authors： Myllynen P,Pasanen M,Pelkonen O

更新日期：2005-05-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are involved in placental remodelling throughout pregnancy. Diabetes mellitus induces alterations in tissue production of NO, a regulator of MMPs activity. The present work evaluates placental and fetal MMPs and NO levels during midpregnancy in neonatal streptozotocin-induced diabetic ...

journal_title：Placenta

authors： Pustovrh MC,Jawerbaum A,Capobianco E,White V,López-Costa JJ,González E

更新日期：2005-04-01 00:00:00

abstract：:Placental pathology is a valuable link explaining how underlying pregnancy risk factors result in adverse pregnancy outcome. This potentially useful information is currently underutilized due to a general lack of rigor in placental diagnosis. This lack of rigor is in large part due to a failure to appreciate the impor...

journal_title：Placenta

authors： Redline RW,Heller D,Keating S,Kingdom J

更新日期：2005-04-01 00:00:00

abstract：:The proliferation and differentiation of trophoblast cells is under the control of a variety of hormones and growth factors and is influenced by nutrient availability. The intracellular signaling pathways acting downstream of these mitogenic factors and nutrients to regulate trophoblast proliferation and placental dev...

journal_title：Placenta

authors： Wen HY,Abbasi S,Kellems RE,Xia Y

更新日期：2005-04-01 00:00:00

abstract：:Alphafetoprotein (AFP) is detectable in maternal serum from around six weeks of gestation and is synthesised by the yolk sac and the fetal liver. The role of the placenta in the transport and possible synthesis of AFP is uncertain. The aim of this study was to investigate placental expression of AFP and the AFP recept...

journal_title：Placenta

authors： Newby D,Dalgliesh G,Lyall F,Aitken DA

更新日期：2005-02-01 00:00:00

abstract：:During pregnancy, leptin concentrations in the maternal circulation are elevated in both humans and rodents but decrease to pre-pregnancy levels at birth, suggesting a role for leptin in the maintenance of pregnancy. Synthesis of leptin by the human placenta is established but whether the murine placenta synthesizes l...

journal_title：Placenta

authors： Malik NM,Carter ND,Wilson CA,Scaramuzzi RJ,Stock MJ,Murray JF

更新日期：2005-01-01 00:00:00

abstract：:Placentas from women with preeclampsia overexpress the hypoxia-inducible transcription factor proteins, HIF-1alpha and -2alpha (Rajakumar 2001, Biol Reprod 64; p499-506 and p1019-1020). As a first step in evaluating whether HIF-alpha overexpressed in preeclamptic placentae is capable of transactivation, we tested its ...

journal_title：Placenta

authors： Rajakumar A,Brandon HM,Daftary A,Ness R,Conrad KP

更新日期：2004-11-01 00:00:00

abstract：:The aim of our work was to investigate the presence of non-selective cation channels (NSCC) in freshly isolated smooth muscle cells from the human umbilical artery (HUA), one of the vessels involved in fetal-placental circulation. We studied the electrophysiological properties of NSCC using the patch-clamp technique i...

journal_title：Placenta

authors： Raingo J,Rebolledo A,Iveli F,Grassi de Gende AO,Milesi V

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To study the expression of angiotensin II (ANG II) receptor subtype 1 (AT(1)R) in the human placenta with pregnancy-induced hypertension (PIH). METHODS:Immunohistochemistry was used to detect the expression of AT(1)R in placental tissues of 30 patients with PIH and 10 patients with normal pregnancies (contro...

journal_title：Placenta

authors： Thapa L,He CM,Chen HP

更新日期：2004-08-01 00:00:00

abstract：:Placental trophoblast syncytialization is a unique biological process. We have studied the time course of this process using DNA microarray in a cell model of syncytialization (the cytotrophoblast cell line BeWo following increased intracellular cAMP by forskolin). Total RNA was extracted from BeWo cells and labelled-...

journal_title：Placenta

authors： Kudo Y,Boyd CA,Sargent IL,Redman CW,Lee JM,Freeman TC

更新日期：2004-07-01 00:00:00

abstract：:Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...

journal_title：Placenta

authors： Demir R,Kayisli UA,Seval Y,Celik-Ozenci C,Korgun ET,Demir-Weusten AY,Huppertz B

更新日期：2004-07-01 00:00:00

abstract：:The placenta provides all energy and nutrient requirements for healthy fetal development. The placenta in rats is capable of storing glycogen, although the placenta cells must therefore mobilize stored glycogen to its own glucose supply. Moreover, maternal glucose and/or placental lactate furnished the fetal growth. A...

journal_title：Placenta

authors： Toledo MT,Gomes Marcondes MC

更新日期：2004-05-01 00:00:00

abstract：:The diversity of placental structures in Eutherian mammals is such that drawing generalizations from the definitive forms is problematic. There are always areas of reduced interhaemal distance whether the placenta is epitheliochorial, synepitheliochorial, endotheliochorial or haemochorial. However, the thinning may be...

journal_title：Placenta

authors： Enders AC,Carter AM

更新日期：2004-04-01 00:00:00

abstract：:A long and productive history of studies at high altitude has demonstrated that chronic hypoxia plays a key role in the aetiology of intrauterine growth restriction (IUGR) and pre-eclampsia. Susceptibility to altitude-associated IUGR varies among high-altitude populations in relation to their duration of altitude expo...

journal_title：Placenta

authors： Moore LG,Shriver M,Bemis L,Hickler B,Wilson M,Brutsaert T,Parra E,Vargas E

更新日期：2004-04-01 00:00:00

abstract：:Maternal infection of Trypanosoma cruzi is associated with premature births, abortions and placentitis. A decrease in EGF levels has been suggested to occur in animals infected by T. cruzi, but there is no research about the levels of EGF in human patients with Chagas' disease. We evaluated serum EGF levels in pregnan...

journal_title：Placenta

authors： Lin S,Sartori MJ,Mezzano L,de Fabro SP

更新日期：2004-04-01 00:00:00

abstract：:Neutral endopeptidase 24.11 (NEP) is known to regulate cellular functions by degrading several bioactive peptides, such as gonadotropin-releasing hormone (GnRH). The present study was performed to clarify the mechanisms of NEP expression by GnRH in human choriocarcinoma (BeWo) cells. GnRH increased NEP expression and ...

journal_title：Placenta

authors： Kikkawa F,Shibata K,Suzuki T,Kajiyama H,Ino K,Nomura S,Mizutani S

更新日期：2004-02-01 00:00:00

abstract：:Recently, the gene encoding a new stress-induced protein termed reducing agent and tunicamycin-responsive protein (RTP) was identified. The function of RTP is unknown, however, the strong upregulation of RTP during cellular differentiation, and exposure to stress conditions including hypoxia suggests a specific role f...

journal_title：Placenta

authors： Gratton RJ,Gluszynski M,Nygard K,Mazzuca DM,Graham CH,Han VK

更新日期：2004-01-01 00:00:00

abstract：:Endothelium-derived nitric oxide (NO) plays a key role in the regulation of vascular tone in health and disease. The present study addresses the contribution of NO to the baseline vascular tone in the fetal placental circulation of type 1 diabetic women. To this end, we performed ex-vivo dual perfusions of isolated co...

journal_title：Placenta

authors： Bisseling TM,Wouterse AC,Steegers EA,Elving L,Russel FG,Smits P

更新日期：2003-11-01 00:00:00

abstract：:Chemokines are small polypeptides that attract specific leukocyte subsets by binding to cell-surface receptors. In reproductive biology, they have been implicated in ovulation, menstruation, and embryo implantation, and pathological processes such as preterm delivery, HIV infection, and endometriosis. It is known that...

journal_title：Placenta

authors： Dominguez F,Pellicer A,Simon C

更新日期：2003-10-01 00:00:00

abstract：:Somatic gene delivery in utero is a novel approach to gene therapy for genetic disease. It is based on the concept that application of gene therapy vectors to the fetus in utero may prevent the development of early disease related tissue damage, may allow targeting of otherwise inaccessible organs, tissues and still e...

journal_title：Placenta

authors： Coutelle C,Themis M,Waddington S,Gregory L,Nivsarkar M,Buckley S,Cook T,Rodeck C,Peebles D,David A

更新日期：2003-10-01 00:00:00

abstract：:The IPL/TSSC3 gene is expressed nearly exclusively from the maternal allele, and its protein product acts to limit placental growth in mice. This protein specifically marks Type II trophoblast in the labyrinthine layer of the mouse placenta. To investigate mouse-human homologies, we carried out immunohistochemistry wi...

journal_title：Placenta

authors： Saxena A,Frank D,Panichkul P,Van den Veyver IB,Tycko B,Thaker H

更新日期：2003-09-01 00:00:00

abstract：:Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...

journal_title：Placenta

authors： Duncan JR,Cock ML,Rees S,Harding R

更新日期：2003-08-01 00:00:00

abstract：:The morphometric oxygen diffusive conductance (D(p)) of the placenta provides a measure of the efficiency of oxygen transfer between the mother and the developing fetus. Any change in the D(p)may point towards possible adaptation in the light of altered oxygen transfer. Placentae from normal (n=40) and small for gesta...

journal_title：Placenta

authors： Ansari T,Fenlon S,Pasha S,O'Neill B,Gillan JE,Green CJ,Sibbons PD

更新日期：2003-07-01 00:00:00

abstract：:Neonates born after pregnancies complicated by diabetes or intrauterine growth restriction (IUGR) have increased incidence of hypocalcaemia. Furthermore, IUGR is associated with reduced bone mineralization in infancy and osteoporosis in adult life. We tested the hypothesis that placental calcium transport is altered i...

journal_title：Placenta

authors： Strid H,Bucht E,Jansson T,Wennergren M,Powell TL

更新日期：2003-05-01 00:00:00

abstract：:Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...

journal_title：Placenta

authors： Guibourdenche J,Frendo JL,Pidoux G,Bertin G,Luton D,Muller F,Porquet D,Evain-Brion D

更新日期：2003-05-01 00:00:00

abstract：:The central role of the placenta in the pathogenesis of pre-eclampsia is undisputed. The evidence that maternal syndrome of pre-eclampsia is caused by a maternal systemic inflammatory response (MSIR) is reviewed. The polymorphic nature of the inflammatory network explains the diversity of the varied signs of this cond...

journal_title：Placenta

authors： Redman CW,Sargent IL

更新日期：2003-04-01 00:00:00

abstract：:The aim of this work was to characterize the uptake of 1-methyl-4-phenylpyridinium (MPP(+)) in the JAR human choriocarcinoma cell line. As JAR cells, as well as the placenta, express the neuronal serotonin transporter (SERT), a comparison between the uptake of (3)H-MPP(+) and (3)H-serotonin ((3)H-5HT) was made. Specif...

journal_title：Placenta

authors： Martel F,Keating E

更新日期：2003-04-01 00:00:00